We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Intranasal Lidocaine for Treatment of Migraine

Carolyn J. Sachs, MD, MPH
JAMA. 1996;276(19):1553-1554. doi:10.1001/jama.1996.03540190025022.
Text Size: A A A
Published online


To the Editor.  —Dr Maizels and colleagues1 provide an interesting discussion of a hypothesized mechanism of migraine headache pain. However, I am concerned how, if at all, clinicians will use this information. The 55% efficacy of intranasal lidocaine is significantly lower than that reported for other headache medications (eg, prochlorperazine, 82%2; and sumatriptan, 75%3) administered in urgent care and emergency department settings. According to the authors, this efficacy may be inflated because the adverse effects of intranasal lidocaine likely allowed patients to discover when they received the study medication.Although the relapse rate of 42% for patients treated with intranasal lidocaine is comparable with that for sumatriptane, 5 of the 29 responders were lost to follow-up. Had these 5 patients experienced recurrence of their headaches, the relapse rate would be as high as 52%. Moreover, the authors note that adverse effects were limited to nasal and ocular burning and numbness,


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.