Continuous Intrathecal Baclofen Infusion for Spasticity of Cerebral Origin

A. Leland Albright, MD; Wendy B. Barron, PT; M. Pat Fasick, OTR/L; Paul Polinko, MSW, LSW; Janine Janosky, PhD
JAMA. 1993;270(20):2475-2477. doi:10.1001/jama.1993.03510200081036.
Text Size: A A A
Published online

Objective.  —To determine if continuous intrathecal baclofen infusion (CIBI) would provide continuous relief of spasticity in patients with spasticity of cerebral origin, especially children with cerebral palsy.

Design.  —Prospective, unblinded trial, before and after CIBI.

Setting.  —Children's Hospital of Pittsburgh (Pa).

Patients.  —Thirty-seven patients, 5 to 27 years of age, with spasticity of cerebral origin.

Intervention.  —Continuous intrathecal baclofen infusion for 3 to 48 months.

Main Outcome Measures.  —Muscle tone, range of motion, upper extremity timed tasks, activities of daily living (ADLs).

Results.  —Six and 12 months after CIBI, muscle tone was significantly decreased in the upper (P=.04) and lower (P=.001) extremities. There was a significant relationship between baclofen dosage and muscle tone in the upper (P=.02) and lower (P=.001) extremities. Hamstring motion, upper extremity function, and ADLs were significantly improved in 25 patients who were capable of self-care.

Conclusion.  —Spasticity of cerebral origin can be effectively treated with CIBI. Because baclofen dosages can be titrated for the desired clinical response, CIBI is particularly useful for patients who need some spasticity to stand and ambulate.(JAMA. 1993;270:2475-2477)


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.