We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Blood Dycrasias and Hematologic Reactions in Ticlopidine Users

Diane K. Wysowksi, PhD; Janos Bacsanyi, MD
JAMA. 1996;276(12):952. doi:10.1001/jama.1996.03540120030022.
Text Size: A A A
Published online


To the Editor.  —Ticlopidine hydrochloride (Ticlid, Roche Laboratories, Nutley, NJ) is an antiplatelet drug that has been marketed in the United States since October 1991. Based on reports since then, the labeling of ticlopidine has been changed. Ticlopidine is indicated to reduce the risk of thrombotic stroke in patients who have experienced stroke precursors or had a completed stroke, and it should be reserved for patients who are intolerant of aspirin therapy indicated to prevent stroke. The product labeling as approved in 1991 included a boxed warning that states neutropenia occurred in 2.4% and severe neutropenia and/or agranulocytosis occurred in 0.8% of stroke patients who received ticlopidine in premarketing clinical trials. Reports in the medical literature suggest that ticlopidine may also be associated with aplastic anemia and thrombotic thrombocytopenic purpura.1-3 In a preliminary worldwide search of adverse hematologic events associated with ticlopidine through 1994, a total of 645 cases


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.