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Cefaclor and Serum Sickness-Like Reaction

Ronald D. Reynolds, MD
JAMA. 1996;276(12):950. doi:10.1001/jama.1996.03540120028017.
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To the Editor.  —I disagree with Dr Grammer's1 admonition that all β-lactam drugs should be avoided in patients who experience a serum sickness reaction to cefaclor. He offers no firm evidence that these patients ever develop serum sickness from other β-lactam drugs. In fact, he cites an article that demonstrates that it is safe to give other cephalosporins to these patients.2Over the past 9 years, my 3 partners and I have seen about 10 classic serum sickness reaction to cefaclor. We have not avoided subsequent prescription of β-lactam drugs in these patients. Although their reports are anecdotal, none of these patients has had a subsequent serum sickness reaction to any other β-lactam drug.At the time of a 9-month-old patient's cefaclor serum sickness reaction in February 1991, I had a conversation with Jennifer Stotka, MD, at the Medical Department of Eli Lilly and Co, the manufacturer. I


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