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Effects of Famotidine vs Antacid on Gastric Acidity: Onset of Action and Symptom Relief

Dennis L. Decktor, PhD; Patrick E. Ciccone, MD
JAMA. 1996;276(11):873-874. doi:10.1001/jama.1996.03540110027024.
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To the Editor.  —The article by Dr Feldman1 compares the acid-reducing capacities of over-the-counter famotidine with calcium carbonate antacid. We have confidence in Feldman's overall findings as they pertain to the relative duration of effects of each agent on gastric acidity; however, one should exercise great caution before extrapolating the findings from a highly controlled, pharmacodynamic assessment of gastric acidity to an interpretation of clinically relevant symptom relief.The results of several large symptom-based heartburn studies contradict the reported delayed onset of famotidine's antisecretory action in the article by Feldman. These studies clearly demonstrated the efficacy of low-dose famotidine both in treating and in preventing heartburn symptoms in a far earlier time frame than suggested by Feldman's pharmacodynamic data. In 2 such studies2 (N. Laird, PhD, written communication, March 26, 1996), data collected from 1100 patients with heartburn demonstrated significant symptom relief (vs placebo) as early as 15


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