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ARTICLE |

Risk for Perinatal HIV-1 Transmission According to Maternal Immunologic, Virologic, and Placental Factors

Michael E. St. Louis, MD; Munkolenkole Kamenga, MD; Christopher Brown, MD; Ann Marie Nelson, MD; Tarande Manzila, MD; Veronique Batter, MS; Frieda Behets, MPH; Uwa Kabagabo, MD; Robert W. Ryder, MD; Margaret Oxtoby, MD; Thomas C. Quinn, MD; William L. Heyward, MD
JAMA. 1993;269(22):2853-2859. doi:10.1001/jama.1993.03500220039023.
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Objective.  —To evaluate how maternal and obstetric factors interact to influence mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission.

Design.  —Prospective, observational cohort study of children born to HIV-infected women to determine child's HIV infection status. The analysis then compared peripartum maternal, placental, and obstetric variables between HIV-1 transmitter and nontransmitter women.

Setting.  —Two large maternity wards in Kinshasa, Zaire.

Participants.  —Consecutive sample of 324 HIV-1—infected women at delivery, with 254 HIV-seronegative women followed up as control subjects.

Principal Outcome Measures.  —HIV infection status of children, to classify each woman as an HIV-1 transmitter or nontransmitter.

Results.  —The highest transmission risk (TR) was associated with maternal p24 antigenemia (TR, 71%; relative risk [RR], 3.0; 95% confidence interval [CI], 1.7 to 5.2) and maternal CD8+ lymphocyte counts of at least 1.80×109/L (1800/μL) (TR, 50%; RR, 2.2; 95% CI, 1.2 to 4.2). Among women with CD8+ lymphocyte counts of less than 1.80×109/L, CD4+ lymphocyte counts of less than 0.60×109/L were a risk factor (TR, 29%; RR, 2.2; 95% CI, 1.2 to 4.2). In women with neither high CD8+ nor low CD4+ lymphocyte counts, placental membrane inflammation was associated with perinatal transmission (TR, 40%; RR, 4.2; 95% CI, 1.3 to 13.7). In women with neither p24 antigenemia, high CD8+ or low CD4+ lymphocyte counts, nor placental membrane inflammation, the transmission risk was only 7%. Additional correlates of transmission included maternal anemia and fever, but not maternal sexually transmitted diseases.

Conclusions.  —Identifiable subgroups of HIV-1—infected women based on maternal and placental characteristics had between a 7% and 71% risk of perinatal HIV-1 transmission. Not only the overall rate of transmission but the impact of different risk factors for transmission appear to vary over the course of HIV infection.(JAMA. 1993;269:2853-2859)

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