0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

High-Dose Epinephrine in Cardiopulmonary Resuscitation

Kenneth Polin, MD; Jerrold B. Leikin, MD
JAMA. 1993;269(11):1383. doi:10.1001/jama.1993.03500110051020.
Text Size: A A A
Published online

To the Editor.  —We read with interest and disappointment of the failure of high-dose epinephrine to improve neurological outcome in cases of adult cardiac arrest.1 We report our limited experience in resuscitation of infants and children with high-dose epinephrine.Four children ranging in age from 11 days to 3 years experienced witnessed cardiopulmonary arrests. The initial treatment according to the advanced cardiac life support standards failed to produce a clinical response. In a last-ditch attempt to revive the children, we initiated a continuous infusion with pressor agents. In the first patient, dopamine hydrochloride (20 μg/kg per minute), dobutamine (20 μg/kg per minute), and epinephrine (10 μg/kg per minute) were given with a resultant ventricular fibrillation rhythm. The patient was then successfully defibrillated and stabilized though severe hypoxemic encephalopathy followed. The technique was used twice afterward with a similar response by the heart. In one of these cases, the patient

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();