Dr Kliks' account of two confirmed cases of symptomatic Anisakis infections provides important documentation of an increased variety of fish and squid associated with this disease in the United States. Even with this report, documented cases of human anisakiasis from the United States total less than 30. Moreover, his report emphasizes that Anisakis continues to produce overt illness as opposed to other anisakid nematodes, which rarely produce mild symptoms in humans before spontaneous expulsion.Since Anisakis causes most cases of nontrivial human anisakiasis, focusing on the frequency of this genus in commercial fish should best clarify the issue from the perspective of human disease. Of the fish surveys that Dr Kliks cites, only Myers' investigation found Anisakis with any regularity in the edible flesh of fish other than salmon or herring. Of the three other articles, one (Grainger) is only a description of larvae and gives no frequencies.