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Recommendations for Use of Folic Acid to Reduce Number of Spina Bifida Cases and Other Neural Tube Defects

JAMA. 1993;269(10):1233-1238. doi:10.1001/jama.1993.03500100029008.
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Laurence KM, James N, Miller M, et al.  Double blind randomized controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. Br Med J 1981;282:1509-11.
Link to Article[[XSLOpenURL/10.1136/bmj.282.6275.1509]]
MRC Vitamin Study Research Group.  Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-7.
Link to Article[[XSLOpenURL/10.1016/0140-6736(91)90133-A]]
Smithells RW, Nevin NC, Seller MJ, et al.  Further experience of vitamin supplementation for the prevention of neural tube defect recurrences. Lancet 1983;1: 1027-31.
Link to Article[[XSLOpenURL/10.1016/S0140-6736(83)92654-5]]
Vergel RG, Sanchez LR, Heredero BL, et al.  Primary prevention of neural tube defects with folic acid supplementation: Cuban experience. Prenat Diagn 1990;10:149-52.
Link to Article[[XSLOpenURL/10.1002/(ISSN)1097-0223]]
Mulinare J, Cordero JF, Erickson JD, Berry RJ.  Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA 1988;260:3141-5.
Link to Article[[XSLOpenURL/10.1001/jama.1988.03410210053035]]
Bower C, Stanley FJ.  Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia. Med J Aust 1989;150:613-9.
Mills JL, Rhoads GG, Simpson JL, et al.  The absence of a relation between the periconceptional use of vitamins and neural-tube defects. N Engl J Med 1989;321:430-5.
Link to Article[[XSLOpenURL/10.1056/NEJM198908173210704]]
Milunsky A, Jick H, Jick SS, et al.  Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA 1989;262: 2847-52.
Link to Article[[XSLOpenURL/10.1001/jama.1989.03430200091032]]
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Link to Article[[XSLOpenURL/10.1001/jama.1989.03430120083026]]
National Academy of Sciences. Nutrition during pregnancy . Institute of Medicine, Food and Nutrition Board. Washington, DC: National Academy Press, 1990:365.
Moss AJ, Levy AS, Kim I, et al. Use of vitamin and mineral supplements in the United States: current users, types of products, and nutrients . Hyattsville, MD: National Center for Health Statistics, 1989 (Advance data, No. 174).
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Link to Article[[XSLOpenURL/10.1097/00006250-198606000-00002]]
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CDC.  Use of folic acid for prevention of spina bifida and other neural tube defects—1983-1991. MMWR 1991;40:513-6.


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