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Recommendations for Use of Folic Acid to Reduce Number of Spina Bifida Cases and Other Neural Tube Defects

JAMA. 1993;269(10):1233-1238. doi:10.1001/jama.1993.03500100029008.
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Laurence KM, James N, Miller M, et al.  Double blind randomized controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. Br Med J 1981;;282:1509-11.
MRC Vitamin Study Research Group.  Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 1991;;338:131-7.
Smithells RW, Nevin NC, Seller MJ, et al.  Further experience of vitamin supplementation for the prevention of neural tube defect recurrences. Lancet 1983;;1: 1027-31.
Vergel RG, Sanchez LR, Heredero BL, et al.  Primary prevention of neural tube defects with folic acid supplementation: Cuban experience. Prenat Diagn 1990;;10:149-52.
Mulinare J, Cordero JF, Erickson JD, Berry RJ.  Periconceptional use of multivitamins and the occurrence of neural tube defects. JAMA 1988;;260:3141-5.
Bower C, Stanley FJ.  Dietary folate as a risk factor for neural-tube defects: evidence from a case-control study in Western Australia. Med J Aust 1989;;150:613-9.
Mills JL, Rhoads GG, Simpson JL, et al.  The absence of a relation between the periconceptional use of vitamins and neural-tube defects. N Engl J Med 1989;;321:430-5.
Milunsky A, Jick H, Jick SS, et al.  Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA 1989;;262: 2847-52.
Czeizel AE, Fritz G.  Letter to editor. JAMA 1989;; 262:1634.
National Academy of Sciences. Nutrition during pregnancy . Institute of Medicine, Food and Nutrition Board. Washington, DC: National Academy Press, 1990;:365.
Moss AJ, Levy AS, Kim I, et al. Use of vitamin and mineral supplements in the United States: current users, types of products, and nutrients . Hyattsville, MD: National Center for Health Statistics, 1989; (Advance data, No. 174).
Grimes DA.  Unplanned pregnancies in the U.S. Obstet Gynecol 1986;;67:438-42.
Beck WS.  Pernicious anemia.  In: Wyngaarden JB, Smith LH, eds. Cecil textbook of medicine , 18th ed. Philadelphia: WB Saunders, 1988;.
CDC.  Use of folic acid for prevention of spina bifida and other neural tube defects—1983-1991. MMWR 1991;;40:513-6.

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