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Isoniazid Chemoprophylaxis

Stefan Grzybowski, MD, FRCP
JAMA. 1986;255(12):1615. doi:10.1001/jama.1986.03370120093030.
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The idea of isoniazid chemoprophylaxis was first conceived over 30 years ago by a group of workers in the Public Health Service led by the late Dr Carrol Palmer. A series of excellently conducted trials followed, directed by Drs Shirley Ferebee Wolpert and George Comstock, showing that isoniazid prophylaxis reduces morbidity from tuberculosis by some 50% to 80% in individuals who took the drug for a period of 12 months.1

We realized at that time that in North America the stage had been reached where the majority (perhaps as many as 80%) of all the cases of active tuberculosis were arising as a result of remotely acquired infection in persons infected many years, often a number of decades, previously.2 We estimated that if these previously infected tuberculin-positive individuals would take isoniazid for one year, we could reduce tuberculosis morbidity in North America by at least half.

Sporadic attempts


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