0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Estrogen Withdrawal Syndrome

S. S. C. Yen, MD, DSc
JAMA. 1986;255(12):1614-1615. doi:10.1001/jama.1986.03370120092029.
Text Size: A A A
Published online

Nearly a decade ago, I proposed the term "estrogen withdrawal syndrome" to emphasize the importance of health and well-being and socioeconomic impacts during and after the transition of menopause.1 While menopause is a component of the complex process of aging, a well-recognized set of functional changes is attributable to estrogen withdrawal, such as hot flushes and accelerated bone loss. Women with gonadal dysgenesis, who have never had normal levels of endogenous estrogen, do not experience flushes even at an advanced age. However, when estrogen is administered for several months and then treatment is discontinued, these women experience classic menopausal flushes for the first time.1 This observation suggests that menopausal flushes are a manifestation of a classic withdrawal syndrome, mediated through functional changes of estrogen-sensitive neurons within the brain, which are linked to thermoregulation.2,3

The long-term and more serious consequence of estrogen deficiency is the accelerated bone loss,

Topics

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();