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Declining Incidence of Haemophilus influenzae Type b Disease Since Introduction of Vaccination

Trudy V. Murphy, MD; Karen E. White, MPH; Patricia Pastor, MS; Linda Gabriel; Francinne Medley; Dan M. Granoff, MD; Michael T. Osterholm, PhD, MPH
JAMA. 1993;269(2):246-248. doi:10.1001/jama.1993.03500020080036.
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Objective.  —To determine the incidence of invasive Haemophilus influenzae type b disease in children living in Minnesota and Dallas County, Texas, before and since introduction of plain polysaccharide vaccine in 1985, and conjugate vaccine in 1988. Initially, use of these vaccines was limited to infants 18 months of age and older.

Design.  —Identification of culture-proven cases of H influenzae type b disease was through systems of active, laboratory-based surveillance. The mean incidence of disease (cases observed/100 000 child-years) for 1983 and 1984 served as a baseline for comparison with subsequent years through 1991.

Participants.  —Children less than 5 years of age in Minnesota and Dallas County, Texas. Overall, there were 2557 confirmed age-eligible cases of invasive H influenzae type b disease from 1983 through 1991.

Results.  —Between the 1983-1984 baseline and 1991, the incidence of H influenzae type b disease decreased 85% in Minnesota and 92% in Dallas. Notably, declines in incidence were observed in children in the age group being vaccinated as well as in infants younger than 18 months of age prior to introduction of vaccination.

Conclusion.  —In two widely separated areas of the United States, a profound decrease in the incidence of H influenzae type b disease has occurred. The data suggest that vaccination may be protecting against disease, as well as decreasing the spread of infection to unvaccinated infants.(JAMA. 1993;269:246-248)


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