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Oral Contraceptives and Chlamydia Infections

Stanley A. Gall, MD
JAMA. 1986;255(1):38. doi:10.1001/jama.1986.03370010040016.
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To the Editor.—  Before conclusions are drawn that oral contraceptives (OCs) do not protect against pelvic infections (PID) caused by Chlamydia trachomatis,1 a somewhat more critical examination of the literature may be in order. The highest incidence of chlamydial infection has been shown to occur in women younger than 25 years2,3; the highest percentage of women using OCs is also in this age group.3,4 Chlamydial infection is more common in single and divorced women than in married women,2,3,5 in women whose partners have experienced recent nonspecific urethritis,5 and is also associated with having more than one sex partner2 and with nulliparity.2,3There is no correction for the effects of these apparent risk factors in any of the case-control studies cited by Washington et al1 in which OC use has been associated with increased incidence of chlamydial infection. It is difficult to know


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