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Lymphomatoid Granulomatosis

Jack G. Rabinowitz, MD; Burton A. Cohen, MD; David S. Mendelson, MD
JAMA. 1985;254(24):3458-3460. doi:10.1001/jama.1985.03360240070037.
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LYMPHOMATOID granulomatosis (LYG) is a disease entity that shares clinical and histological features with several lesions that affect the lung. The basic histological characteristics of these lesions consist of a combination of granulomatosis and destructive angiitis.1,2 Our experience with six patients with this entity afforded the opportunity to study the radiological changes and to compare them with those previously described in the literature, as well as with the other granulomatous lesions in this category. The diagnosis of LYG in our cases was confirmed by open-lung biopsy.

Radiological Features  Although the pulmonary manifestations of LYG have been described as fluctuating in presentation and appearance, a few findings in our patients appeared consistent and characteristic. In general, the most typical presentation of LYG consists of a bilateral distribution of multiple nodular densities that tend to favor the basilar pulmonary segments (Figs 1 and 2).3 Five of our six patients as


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