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Intracranial Calcification in Nephrogenic Diabetes Insipidus

Susumu Kanzaki, MD; Tsutomu Omura, MD; Masako Miyake, MD; Sumiko Enomoto, MD; Ichiro Miyata, MD; Hiroshi Ishimitsu, MD
JAMA. 1985;254(23):3349-3350. doi:10.1001/jama.1985.03360230081028.
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NEPHROGENIC diabetes insipidus (NDI) is a congenital hereditary disorder characterized by insensitivity of the renal tubule to antidiuretic hormone. This congenital hereditary disorder has been associated with a number of central nervous system complications.1,2 However, intracranial calcification is an extremely rare complication of this disorder.3 We describe a 2-year-old boy with NDI who presented with a unique pattern of intracranial calcification. Our case shows that NDI may result in organic brain damage if treatment is delayed.

Report of a Case  A boy 2 years 11 months old was admitted to our hospital because of a seizure. He was the product of a normal pregnancy, labor, and delivery of a 30-year-old, gravida 3, para 1, abortus 2 woman. The parents are not related and are of Japanese extraction. His birth weight was 2,900 g. He was given an Apgar score of 9 at both one and five minutes after


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