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Article |

Baboon-to-Human Cardiac Xenotransplantation in a Neonate

Leonard L. Bailey, MD; Sandra L. Nehlsen-Cannarella, PhD; Waldo Concepcion, MD; Weldon B. Jolley, PhD
JAMA. 1985;254(23):3321-3329. doi:10.1001/jama.1985.03360230053022.
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This report details the first case of cardiac xenotransplantation in a neonate. The recipient, a victim of hypoplastic left heart syndrome (HLHS), survived 20 days. Autopsy findings are documented. The cardiac graft showed only traces of cell-mediated rejection. Graft failure appears to have resulted from a progressive, potentially avoidable humoral response, unmodified by immunosuppression. Cardiac allotransplantation and selective baboon-to-human xenotransplantation deserve further exploration as investigational therapy for neonatal HLHS.

(JAMA 1985;254:3321-3329)


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