We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Alzheimer's Disease and Corticotropin-Releasing Factor

L. W. Swanson, PhD
JAMA. 1985;254(21):3085-3086. doi:10.1001/jama.1985.03360210101041.
Text Size: A A A
Published online


Two subjects of broad interest to the basic and medical sciences have found a common ground in the accompanying article by Bissette and colleagues.1 Alzheimer's disease is a common form of senile dementia with severe effects on cognition and affect. It has been studied intensely in recent years because a firm diagnosis can be made postmortem on the basis of neurofibrillary tangles and neuritic plaques, which are most common in the cerebral cortex, particularly in the hippocampal formation. Nothing is known with certainty about the etiology of Alzheimer's disease, although current interest has been sparked by the discovery that levels of the neurotransmitter acetylcholine are severely depleted in the hippocampus and other parts of the cerebral cortex in patients with the disorder.2 This finding was of particular interest in view of evidence that the hippocampus plays a critical role in short-term memory, and the more permanent consolidation of


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.