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Minocycline-Associated Tooth Discoloration in Young Adults

Susana C. Poliak, MD; John J. DiGiovanna, MD; Earl G. Gross, MD; Gail Gantt, RN; Gary L. Peck, MD
JAMA. 1985;254(20):2930-2932. doi:10.1001/jama.1985.03360200082032.
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After observing a patient with adult-onset tooth discoloration coincident with minocycline administration, we retrospectively surveyed a cohort of patients with severe cystic acne during therapeutic trials with isotretinoin. Four of 72 patients who had minocycline therapy during adolescence were found to have minocycline-associated tooth discoloration, which occurred in one case after only four weeks of treatment. Thus, minocycline must be considered as an uncommon cause of tooth staining in adults.

(JAMA 1985;254:2930-2932)


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