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Evidence for a 1980 HTLV-III Infection in a Currently Asymptomatic B Hemophiliac in Italy

Oliviero E. Varnier, MD; Giovanni Melioli, MD; Annalisa Merli, PhD; Gian Carlo Schito, MD; Gabriela Tudor, PhD; Elio Boeri, MD; Angelo C. Molinari, MD; Pier Giorio Mori, MD
JAMA. 1985;254(11):1449-1450. doi:10.1001/jama.1985.03360110039011.
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To the Editor.—  Seroconversion for antibody to human T-cell lymphotropic virus type III (HTLV-III) in hemophiliacs began shortly after the beginning of the acquired immunodeficiency syndrome (AIDS) epidemic among homesexual men and intravenous drug users (1979-1980). The first case of seropositivity was observed in 1978 in a 2-year-old child who had received blood transfusions as well as factor VIII concentrate.1 The seropositivity among European hemophiliacs has been reported to date back to 19812,3 following exposure to HTLV-III via some factor VIII concentrates obtained from the United States.4We have tested several sequentially collected serum samples (1979 to 1985) from about 100 Italian hemoDetection of Anti-HTLV-III Antibodies by ELISA and Western Blot Assays* Intensity Score for Antibodies to HTLV-III Date of ELISA Serum Collection Index p15 p24 p31 p41 p55 p61 10/28/80 4.7 2 1 0 0 0 0 3/1/85 >15 4 1 3 4 2 2


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