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Article |

Immune Thrombocytopenia Following α-Interferon Therapy in Patients With Cancer

Peter McLaughlin, MD; Moshe Talpaz, MD; Jorge R. Quesada, MD; Abdus Saleem, MD; Barthel Barlogie, MD; Jordan U. Gutterman, MD
JAMA. 1985;254(10):1353-1354. doi:10.1001/jama.1985.03360100103022.
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Immune thrombocytopenia occurred in five patients with cancer receiving α-interferon. The median pretreatment platelet count was 217,000/cu mm, which fell to a median of 12,000/cu mm after a median of 25 days of interferon therapy. All had normal numbers of megakaryocytes, with dysplasia noted in three; all four who were tested had platelet-associated immunoglobulin. All had normalization of platelet counts with prednisone therapy. Four tolerated re-treatment with interferon, two with concurrent prednisone administration and two others following splenectomy. Immune thrombocytopenia should be considered in patients who become thrombocytopenic during interferon therapy.

(JAMA 1985;254:1353-1354)


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