Hormone Replacement Therapy and Breast Cancer Risk-Reply

Ingemar Persson, MD, PhD; Hans-Olov Adami, MD, PhD
JAMA. 1996;275(15):1159-1160. doi:10.1001/jama.1996.03530390024025.
Text Size: A A A
Published online

In Reply.  —Epidemiological data on the association between HRT and breast cancer risk still seem contradictory, both when comparing results of studies from within the United States and studies from the United States and Europe.1-3 Differences in design qualities and in study populations may be important explanations. The comments of Dr Harris and colleagues and Dr Campagnoli and colleagues, however, focus attention on biological mechanisms that might explain why HRT in some circumstances may exert an adverse effect on breast cancer risk.On the basis of subgroup analyses from several studies, Harris et al suggest that, compared with women with normal BMIs, the breast tissue in lean women is exposed to higher concentrations of estrogens, and therefore it may particularly susceptible. It might also be that exogenous hormones have a greater impact in lean women because they have relatively lower endogenous levels before treatment. The breast tissue may be


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.