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Hormone Replacement Therapy and Breast Cancer Risk-Reply

Janet L. Stanford, PhD
JAMA. 1996;275(15):1159. doi:10.1001/jama.1996.03530390024024.
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In Reply.  —The observation that hormone replacement therapy (HRT) may be associated with an increased risk of breast cancer in thin women was supported by our recent study as well as some other investigations. However, we believe that Table 1 and the summary estimate provided by Dr Harris and colleagues may be misleading. The categories of menopausal estrogen use and BMI for which data have been presented differ from study to study, limiting the ability to interpret these data.We have analyzed our own data to illustrate how the relative odds of breast cancer varies across different categories of estrogen use and BMI (Table 3). These data show how dissimilar results may be, depending on the way in which each variable is defined. In addition, it could be that body weight is more important than BMI in assessing risks related to the dose of estrogen a woman receives. However, our


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