Diagnosis and Treatment of Early Melanoma:  NIH Consensus Development Panel on Early Melanoma

Lowell A. Goldsmith, MD; Frederic B. Askin, MD; Alfred E. Chang, MD; Cynthia Cohen, MB, BCh; Janice P. Dutcher, MD; Robert S. Gilgor, MD; Stephanie Green, PhD; Emily L. Harris, PhD, MPH; Stephen Havas, MD, MPH, MS; June K. Robinson, MD; Neil A. Swanson, MD; Margaret A. Tempero, MD; A. Bernard Ackerman, MD; Charles M. Balch, MD; Natale Cascinelli, MD; Wallace H. Clark, MD; Evan R. Farmer, MD; DuPont Guerry IV, MD; Alan N. Houghton, MD; Howard K. Koh, MD; Alfred W. Kopf, MD; Kenneth H. Kraemer, MD; Rona M. MacKie, MD, FRCP, FRCPath, FRSE; John C. Maize, MD; Frank L. Meyskens Jr, MD; Douglas A. Perednia, MD; Michael W. Piepkorn, MD, PhD; Darrell S. Rigel, MD, MS; Gary S. Rogers, MD; Richard W. Sagebiel, MD; Arthur J. Sober, MD; Margaret A. Tucker, MD; Mary R. Wick, MD; John J. Zone, MD; Alan N. Moshell, MD; Elaine Blume; Elsa Bray; Jerry M. Elliott; John H. Ferguson, MD; Mary B. Gregg, MS, MBA; William H. Hall; Donald E. Henson, MD; Stephen I. Katz, MD, PhD; Michael T. Lotze, MD; John Maize, MD; Kavon H. Safavi, MD, MPH; Arthur Sober, MD
JAMA. 1992;268(10):1314-1319. doi:10.1001/jama.1992.03490100112037.
Text Size: A A A
Published online


THE INCIDENCE of melanoma of the skin appears to be rapidly rising. The increased incidence may be partially attributable to increased detection resulting from screening. In 1992, approximately 32000 newly diagnosed cases and 6700 deaths are expected in the United States. Melanoma tends to occur in adults in the prime of their family and professional lives. Detection and surgical treatment of the early stages of this malignancy are usually curative. In contrast, diagnosis and treatment in late stages often have dismal results.

Traits associated with an increased risk of developing melanoma include multiple typical moles, atypical moles, freckling, history of severe sunburn, ease of burning, inability to tan, and light hair with blue eyes. Other factors include the presence of familial atypical mole and melanoma syndrome, disorders of DNA repair, and excessive sun exposure.

Efforts to increase public awareness of melanoma and its treatment without causing unnecessary fear present a


Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours




Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.