We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Sexual Dysfunction Secondary to Topical Ophthalmic Timolol

F. T. Fraunfelder, MD; S. Martha Meyer
JAMA. 1985;253(21):3092-3093. doi:10.1001/jama.1985.03350450064016.
Text Size: A A A
Published online


To the Editor.—  The 34th most common prescription drug in the United States in 1983 was timolol maleate eyedrops (Timoptic). Although unusual and less known systemic side effects are often not recognized as being associated with a patient's eyedrops, the National Registry of Drug-Induced Ocular Side Effects, at Oregon Health Sciences University, Portland, has received over 1,700 case reports of adverse reactions secondary to topical ophthalmic timolol, and 63% of these reports concern systemic effects.Systemic β-blockade has been demonstrated secondary to both systemic and topical ophthalmic administration of β-adrenergic blockers. Sexual dysfunction has been reported in patients using oral β-blockers for angina pectoris or hypertension.1-3 In addition, the registry has compiled 28 complaints of various sexual dysfunctions noted in 25 patients following usual doses of topical ocular timolol. Impotence was reported by 18 patients, decreased libido in nine patients, and decreased ejaculate volume in one patient. Five of


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.