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Physiology, Biochemistry, and Molecular Biology of the Skin

Walter B. Shelley, MD, PhD; E. Dorinda Shelley, MD
JAMA. 1992;268(4):545. doi:10.1001/jama.1992.03490040129042.
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To open this book is to enter a vast cathedral of knowledge about the skin around us. As you walk in, you will see no stained glass, but rather the subdued light from scores of interesting black-and-white illustration windows. Just inside the vestibule is the baptismal font for newborn skin, with insight into the developing structure and ultrastructure of the epidermis and dermis. Behold these wonders of the epidermis: the keratinocyte, which lives to die for your protection; the melanocyte, your shield from the sun; the Langerhans cell, your outermost immune guard; and the Merkel cell, your touch button. You also see the dermis, with collagen and elastic fibers embedded in a glycosaminoproteoglycan gel, and a mesh of blood vessels, lymphatic channels, and nerves. If you peer down into the holes in the epidermis, you will see the wonders of hair, sweat, and oil formation.

As the great doors swing


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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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