—All published data, particularly those on controversial issues, should be carefully analyzed and interpreted by the readers. In addition, other investigators should gather data attempting to replicate and verify the hypothesis. Fortunately, both analytical reading and several evaluations of the New York State triplicate prescription regulations for benzodiazepines have been carried out.The authors of the letters published in this issue of JAMA interpreted the results of our study differently than did my colleagues and I. Publication of their views is a legitimate, important aspect of the research process.Several other investigators have examined the New York State benzodiazepine regulations. Reidenberg1 compared benzodiazepine prescribing in New York and Pennsylvania. His conclusion that the full health consequences of the regulations have not yet been clarified mirrors the opinion my colleagues and I articulated in JAMA.The effects of the regulations have also been examined by Shader et al.