Claude H. Organ Jr, MD; William R. Fry, MD
JAMA. 1992;268(3):413-414. doi:10.1001/jama.1992.03490030125056.
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The impact of molecular biology during 1991 has attained increased importance in the understanding of processes affecting and caused by surgical procedures. Unresectable tumors and the inability of the body to cope with diseased tissues that continue to perform normal functions still require extirpation. Prevention of complications induced by surgical intervention, such as postoperative infection, is beginning to be understood.

Parekh et al1 reported in experimental animals that FOY-305, which stimulates the release of endogenous cholecystokinin, caused both hypertrophy and hyperplasia of pancreatic remnants following distal pancreatectomy. If this can be duplicated in humans, it could have significant implications for patients undergoing pancreatectomy or in patients with pancreatic exocrine insufficiency.

Cheadle et al2 confirmed that peripheral blood monocytes HLA-DR are a reliable marker for clinically significant surgical infections. Clarification of the deficits associated with this marker may open up new methods of prophylaxis and treatment for surgically related


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