0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Free Serum Prostate-Specific Antigen and Screening for Prostate Cancer-Reply

William J. Catalona, MD; Deborah S. Smith, PhD
JAMA. 1996;275(11):838. doi:10.1001/jama.1996.03530350019022.
Text Size: A A A
Published online

In Reply.  —We agree with Dr Bangma and colleagues that additional study is required to determine whether measurement of the percentage of free PSA is the best method for increasing the specificity of PSA screening for prostate cancer detection. Although our study is preliminary, it is encouraging that our results are consistent with reports of other investigators from around the world who have used different study methods and assays.1-3 In the study by Bangma et al,4 using still another assay in men with PSA levels of 4 to 10 ng/mL, a cutoff of 28% free PSA would have detected 91% of cancers and eliminated 19% of negative biopsies; in the subset with a gland volume less than 50 cm3, a cutoff of 19% would have detected 91% of the cancers and eliminated 49% of negative biopsies. The reason for the lower specificity in the study by Bangma

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();