We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

The Effect of Low-Fat Diet on Lipid Levels

Edward Siguel, MD, PhD; Robert H. Lerman, MD, PhD
JAMA. 1996;275(10):759. doi:10.1001/jama.1996.03530340023022.
Text Size: A A A
Published online


To the Editor.  —The study by Dr Schaefer and colleagues1 fills a major gap in understanding the effect of low-fat diets on lipid levels. During their study (approximately 3 months), two (6.9%) of the 29 subjects developed evidence of heart disease; one had a myocardial infarction. At this rate, approximately 25% of subjects would develop evidence of heart disease every year. In our clinical experience we found that low-fat diets using processed low-fat and nonfat foods deprived of essential fatty acids (EFAs) decrease high-density lipoprotein (HDL) levels and increase triglyceride levels. Some patients feel more tired and complain that they lack energy.We have been warning physicians that such low-fat diets increase the ratio of total cholesterol to HDL cholesterol, and deplete plasma and red blood cell EFA levels when used as maintenance diets (ie, without weight loss).2,3 Numerous studies show that low levels of polyunsaturated fatty acids


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.