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Fatal Case of Necrotizing Enterocolitis Associated With Feeding Concentrated Infant Formula

George H. Nelson, PhD, MD; William Z. Catterton III, MD
JAMA. 1985;253(13):1880. doi:10.1001/jama.1985.03350370060021.
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To the Editor.—  Infant formula can currently be purchased in cans that are either "ready-to-feed" or "concentrated liquid." The following case report emphasizes the critical importance of parents' understanding the difference between these two types of formula and following the directions as to dilution.

Report of a Case.—  The patient was a white female, the product of a term gestaton after an uneventful pregnancy, except for maternal hypertension at the time of delivery. The infant was delivered at a nearby local hospital; birth weight was 3,470 g, and Apgar scores were 9 and 10. The infant was fed formula and there was no record of vomiting or diarrhea in the nursery. At 3 days of age, weighing 3,429 g, and in good condition, she was discharged home with her mother. The mother was given some cans of formula with iron labeled "ready-to-feed" and was instructed to feed the formula undiluted.

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