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Detection of Neisseria gonorrhoeae

David L. White, MD, MPH
JAMA. 1985;253(12):1723-1724. doi:10.1001/jama.1985.03350360049015.
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To the Editor.—  In the article entitled "Evaluation of an Enzyme Immunoassay for Detection of Neisseria gonorrhoeae in an Adolescent Population," by Demetriou et al,1 the authors provide some incomplete information about gonorrhea screening using Gonozyme. This test is only useful in urethral and cervical specimens. It cannot be used to detect rectal or pharyngeal infection. Because of the limitations of this test, I have found it not to be helpful in our Sexually Transmitted Disease Clinic for the following reasons: (1) In males with a urethral discharge, a Gram's stain is cheaper and more accurate; where rectal and/or pharyngeal involvement is suspected, a Thayer-Martin culture is still required. (2) In females, a rectal Thayer-Martin culture is routinely performed along with examination of cervical material. A Gram's stain again is often helpful and less expensive than a Gonozyme assay. If pharyngeal contact is suspected, this also requires a Thayer-Martin


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