We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Effects of H2-Receptor Antagonists on Blood Alcohol Levels

James Palmer, FRCP; J. Robert Powell, PharmD; Arthur Euler, MD; Richard L. McIsaac, PhD
JAMA. 1992;267(18):2470. doi:10.1001/jama.1992.03480180055019.
Text Size: A A A
Published online


To the Editor.  —The article by DiPadova et al1 reported that ranitidine and cimetidine, but not famotidine, increase blood alcohol concentrations when 0.3 g/kg ethanol is administered to men in the morning following breakfast. We have several comments and questions about this article.First, ethanol concentrations were measured by three different analytical methods (breath analyzer, plasma enzymatic assay, and plasma gas chromatography) in different subjects. While the authors imply that the methods gave virtually identical results, no further information was presented. Cross-validation of results is essential to exclude systematic differences between such diverse methods. We note that in previous articles published by Frezza et al2 and Caballeria et al3 on ethanol presystemic clearance, only one method was used in each study, rather than three methods.Second, the three assay methods are reported as blood alcohol concentrations. However, blood was not analyzed, and no conversion from plasma to


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.