This is a long book filled with much important pharmacologic information. It appears to be written primarily for persons with a special interest in clinical pharmacology and critical care. It is a good reference text for pharmacology in the intensive care unit (ICU) but does not provide the usual approach to clinical problems that many ICU physicians might prefer.
The initial chapter on pharmacokinetics is complex, but the authors have tried to make it understandable. The next chapter lists many of the more common possible drug interactions and is primarily for reference. The following several chapters dealing with drug adjustments in infants, renal failure, liver failure, and pulmonary failure are extremely helpful.
In many of the chapters I expected much more detailed information, particularly relative to the mode of action, on the drugs commonly used in the ICU. The chapter on colloids and crystalloids and the next chapter on the