We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |


Michael A. Baumann, MD; Joseph A. Libnoch, MD
JAMA. 1984;252(10):1340. doi:10.1001/jama.1984.03350100062034.
Text Size: A A A
Published online


Intense hemophagocytosis by bone marrow histiocytes was observed in a 66-year-old man who had fever, jaundice, hepatosplenomegaly, and pancytopenia. This constellation of findings was originally described by Scott and Robb-Smith1 in 1939 and was termed histiocytic medullary reticulosis because of the characteristic infiltration of the medullary region of the lymph nodes by histiocytes. Rappaport2 renamed the disease malignant histiocytosis in 1966 and emphasized the presence of cytologic atypia of the hemophagocytic histiocytes as a criterion for diagnosis. Malignant histiocytosis is now recognized as one of the rare malignancies of true monocytemacrophage origin and is generally regarded as having a poor prognosis, although some encouraging reports of improved survival following combination chemotherapy have been published in recent years.3

Hemophagocytosis has also been observed accompanying reactive histiocytic proliferation in response to systemic bacterial infections, including miliary tuberculosis, brucellosis, and typhoid.4 Recently, prominent hemophagocytosis was described in association with


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.