We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Disease Detectives Are Turning to Molecular Techniques to Uncover Emerging Microbes

Joan Stephenson, PhD
JAMA. 1996;275(3):176. doi:10.1001/jama.1996.03530270016007.
Text Size: A A A
Published online


ALTHOUGH THE time-honored practice of "shoe-leather epidemiology" has a secure place in investigations of mysterious outbreaks of illness, some recently developed molecular techniques are dramatically expanding the capabilities of infectious disease sleuths and revolutionizing infection control.

Nucleic acid—based techniques are proving valuable not only for identifying emerging pathogens but also for monitoring infections caused by these agents, noted David H. Persing, MD, PhD, at an Institute of Medicine—sponsored meeting. In research reported last year, such techniques enabled Persing, of the Division of Clinical Microbiology and the Molecular Microbiology laboratory at the Mayo Clinic, Rochester, Minn, and colleagues to recover and determine genetic sequences of protozoal DNA in the blood of four patients. The result: identification of a new babesialike piroplasm that can cause a potentially fatal illness.

In addition to helping epidemiologists finger previously unknown pathogens as the cause of disease outbreaks, such molecular tools can help researchers determine potential


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.