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Article |

Pathology of Glomerular Disease

Ashton B. Morrison, MD, PhD
JAMA. 1984;252(8):1064. doi:10.1001/jama.1984.03350080064034.
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This is an up-to-date series of reviews of various aspects of disease of the glomeruli. It opens with an essay by the editor, Dr Rosen, on the classification of glomerular disease.

Despite the extensive accumulation of well-documented observations concerning the various light and electron microscopic changes and the patterns of immunofluorescence in glomerular disease, even the best efforts of the nosologist are thwarted by our limited understanding of the underlying mechanisms of the response of the glomerulus to injury. Dr Rosen offers in his contribution one of the best efforts available in this area. It is accompanied by useful tables culled from other sources, and, while comprehensive, remains brief and readable. Indeed he manages to draw attention to the congenital nephrotic syndromes, and the nail-patella syndrome, which are strangely omitted from the chapter addressing the topic of hereditary nephropathy.

The rest of the chapters cover the various aspects of glomerular


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