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ARTICLE |

Nicotine Replacement Therapy During Pregnancy

Neal L. Benowitz, MD
JAMA. 1991;266(22):3174-3177. doi:10.1001/jama.1991.03470220090034.
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CIGARETTE smoking is a major preventable cause of fetal death and injury, yet many women continue to smoke cigarettes throughout pregnancy. The most effective pharmacologic adjunct to smoking cessation therapy is nicotine replacement, including nicotine chewing gum or transdermal nicotine. However, the use of nicotine replacement therapy is contraindicated during pregnancy. The analysis presented herein suggests that the benefits of nicotine replacement therapy to aid smoking cessation in pregnant women who cannot stop smoking without such therapy substantially outweigh the risks of continued smoking or the risks of nicotine replacement per se.

PREVALENCE OF CIGARETTE SMOKING DURING PREGNANCY  Although the prevalence of smoking has declined in recent years and many women quit smoking when they become pregnant, 20% to 25% of pregnant American women continue to smoke throughout pregnancy; many of these women are heavy smokers. The National Health Interview survey of women pregnant in 1985 or with a birth

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The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
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