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ARTICLE |

Effects of Endurance Training on Glucose Tolerance and Plasma Lipid Levels in Older Men and Women

Douglas R. Seals, PhD; James M. Hagberg, PhD; Ben F. Hurley, PhD; Ali A. Ehsani, MD; John O. Holloszy, MD
JAMA. 1984;252(5):645-649. doi:10.1001/jama.1984.03350050033022.
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Eleven healthy men and women (63 ±1 years) participated in a 12-month endurance-training program to determine the effects of low-intensity and high-intensity training on glucose tolerance and plasma lipids in older persons. Plasma glucose, insulin, and C-peptide concentrations were measured for three hours after ingestion of 100 g of glucose and the total areas under the respective curves were calculated. Total plasma lipids and lipoprotein concentrations were determined during fasting. Maximal oxygen uptake increased 12% during six months of low-intensity training; a further 18% increase occurred during an additional six months of high-intensity training. Glucose tolerance, which was normal initially, was not significantly changed after training. However, the total area for insulin was 8% lower after low-intensity training, and 23% lower after high-intensity training, compared with before training. C-peptide concentrations were similarly reduced. Plasma lipid and lipoprotein concentrations were unchanged after low-intensity training, but high-intensity training resulted in an increase in high-density lipoprotein cholesterol and a reduction in triglycerides. These results demonstrate that older persons respond to prolonged, high-intensity endurance training with an increase in sensitivity to insulin and a favorable alteration in their plasma lipoprotein-lipid profile.

(JAMA 1984;252:645-649)

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