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ARTICLE | January 3, 1996

HIV-1 Shedding and Chlamydial Urethritis

Joseph J. Eron, MD; Bruce Gilliam, MD; Susan Fiscus, PhD; John Dyer, MD; Myron S. Cohen, MD

JAMA. 1996;275(1):36. doi:10.1001/jama.1996.03530250040022.

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To the Editor. —Drs Schmid and Fontanarosa¹ thoroughly discussed the causes and management of nongonococcal urethritis. However, they did not emphasize the link between treatment of sexually transmitted diseases and prevention of human immunodeficiency virus (HIV).² We collected ejaculate from a 32-year-old white man with HIV-1 disease and a CD4 cell count of 0.11×10⁹/L who was taking no antiretroviral therapy. The patient had chlamydial urethritis at the time the sample was obtained, with dysuria but without discharge. We performed quantitative HIV-1 culture on his seminal cell fraction, using a modification of the AIDS Clinical Trials Group quantitative cell culture protocol. We had previously performed 32 quantitative cultures for HIV-1 using seminal cells from 25 HIV-1—infected individuals; the range of excretion was <3.0 to 2523.3 infectious units per ejaculate. Our patient excreted 6729 infectious units of HIV-1 in his ejaculate obtained at the time of chlamydial infection

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Eron JJ, Jr, Gilliam B, Fiscus S, Dyer J, Cohen MS. HIV-1 Shedding and Chlamydial Urethritis. JAMA. 1996;275(1):36. doi:10.1001/jama.1996.03530250040022.

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