0
ARTICLE |

Curious links reported between Down's and Alzheimer's disease

JAMA. 1984;251(14):1806-1812. doi:10.1001/jama.1984.03340380004002.
Text Size: A A A
Published online

ABSTRACT

Curious links have come to light in the past few years between two seemingly unrelated types of mental affliction. Persons with Down's syndrome tend to survive longer because of better care, and those few who live to age 35 or more nearly always develop a form of dementia that closely resembles the clinical picture of patients with a presumptive diagnosis of Alzheimer's disease. Their brains at autopsy show the typical neurofibrillary tangles and senile plaques.

Other links between these disorders also have been observed. For example, Albert Heyman, MD, professor of neurology, Duke University School of Medicine, Durham, NC, recently published results of a study involving 1,200 families of patients with Alzheimer's disease (Ann Neurol 1983;14:507-519). Heyman found that the immediate families of patients with Alzheimer's disease have an incidence of Down's syndrome three times greater than would be expected in the general population.

Such facts have led some investigators

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();