0
ARTICLE |

Caffeine Revisited

William T. Beaver, MD
JAMA. 1984;251(13):1732-1733. doi:10.1001/jama.1984.03340370064033.
Text Size: A A A
Published online

Laska and co-workers1 have mustered impressive new evidence for the efficacy of caffeine as an analgesic adjuvant while simultaneously providing an example of how results from a number of controlled clinical trials, the majority of which do not individually meet the usually accepted levels of statistical significance for verifying a drug effect, may be combined to provide substantial evidence of drug efficacy. Caffeine has long been a constituent of both over-the-counter (OTC) and prescription analgesic combinations in conjunction with aspirin, acetaminophen, phenacetin, and salicylamide. However, critiques have repeatedly noted that the then-available evidence for caffeine's contribution to the efficacy of such combinations was tenuous at best.2-5

The major problem in demonstrating caffeine's contribution is the limited assay sensitivity of controlled clinical trials used to evaluate mild analgesics and their combinations.3 Because of the multiplicity of known and unknown variables that affect the course of a patient's pain

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();