Southern Arizona dermatologists are being asked to enroll patients in a clinical trial involving two skin cancer "chemoprevention" studies.
Both are being conducted by University of Arizona College of Medicine investigators in Tucson in cooperation with physicians in private practice. One study is monitoring the effects of vitamin A in persons who already have multiple skin cancers. The other study seeks to determine the role of isotretinoin (13-cis-retinoic acid) in possibly preventing skin cancer in patients who have actinic keratoses.
Some 2,400 patients are expected to be enrolled eventually. The National Cancer Institute (NCI), Bethesda, Md, has just renewed funding of $1.7 million for three years. The NCI has been studying the effects of vitamins on cancer for more than a decade (JAMA [MEDICAL NEWS] 1976;235:1409-1410 and 1978;240:609-615).
The principal investigator for the multiple skin cancer clinical trial and some related projects is Frank L. Meyskens, Jr, MD,