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Vaccine Challenges, in Addition to Delivery, Include New Formulations, Better Administration

Jody W. Zylke, MD; Charles Marwick
JAMA. 1991;266(10):1322. doi:10.1001/jama.1991.03470100014003.
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EXPERTS AGREE that getting vaccines into those children who need immunization is a high-priority issue.

Although significant attention is being devoted to vaccine delivery, work continues on developing new vaccines and on improving their administration.

Samuel Katz, MD, Duke University School of Medicine, Durham, NC, a member of the Immunization Practices Advisory Committee of the US Public Health Service, and Caroline Breese Hall, MD, University of Rochester (NY) School of Medicine and Dentistry, chair of the American Academy of Pediatrics' Committee on Infectious Diseases, point to some recent developments.

What Might Be Done  Highlights are as follows:

  • Vaccine administration should be simplified.

  • Reducing the number of visits or injections required for a full series of immunizations might improve parental compliance.

    Two manufacturers, Merck Sharp & Dohme, West Point, Pa, and Connaught Laboratories Inc, Swiftwater, Pa, have received permission from the Department of Commerce to collaborate to try to combine four


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