0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
ARTICLE |

Preimplantation Diagnosis of the Cystic Fibrosis ΔF508 Mutation: What of the Other Two Embryos?

Charles W. Callahan, DO; Donald A. Person, MD
JAMA. 1995;274(2):126-127. doi:10.1001/jama.1995.03530020044019.
Text Size: A A A
Published online

To the Editor.  —Dr Liu and colleagues1 recently reported the remarkably successful application of microsurgical techniques of epididymal sperm aspiration and intracytoplasmic sperm injection of stimulated oocytes. Following in vitro fertilization, blastomere biopsy was accomplished by micromanipulation. Analysis of DNA by polymerase chain reaction demonstrated the genotype of the embryos from two cystic fibrosis carriers.Five embryos were successfully fertilized. Two were homozygous for the ΔF508 genotype and three were carriers. These three carriers were transferred to the uterus and one successfully implanted. Subsequently, a phenotypically normal male infant was born.1 The article emphasized the preimplantation diagnosis of cystic fibrosis as well as the father's diagnosis of congenital bilateral absence of the vas deferens. The study, we are told, was approved by the institutional ethics committee. It is impossible to describe the joy that comes from the blessing of parenthood. We who are parents rejoice with this new

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();