We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Alcohol Consumption and Tissue-Type Plasminogen Activator

William E. M. Lands, PhD
JAMA. 1995;273(18):1416. doi:10.1001/jama.1995.03520420028016.
Text Size: A A A
Published online

To the Editor.  —The article by Dr Ridker and colleagues1 associates alcohol consumption with plasma levels of tissuetype plasminogen activator (t-PA) antigen. An accompanying Editorial2 illustrated the problem of complex situations and oversimplified interpretations. Weighing the benefits and risks of alcohol consumption is a serious issue for many Americans, and we should be careful that we do not amplify misunderstandings about underlying causes for the risks and benefits involved.The article failed to note that because fibrinolytic activity is influenced by levels of both the activator (t-PA) and its inhibitor (PAI-1), information on t-PA alone has little utility. The article also failed to acknowledge many prior reports of elevated t-PA associated with alcoholic cirrhosis. There was no evidence of the fibrinolytic status of the subjects or the cardioprotective effect of a 25% difference in plasma t-PA. Finally, the claim on page 932 provided a challenge to all scientists


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.