We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Article |

Apolipoprotein E Type 4 Allele and Cerebral Glucose Metabolism in Relatives at Risk for Familial Alzheimer Disease

Gary W. Small, MD; John C. Mazziotta, MD, PhD; Mark T. Collins; Lewis R. Baxter, MD; Michael E. Phelps, PhD; Mark A. Mandelkern, MD, PhD; Andrea Kaplan; Asenath La Rue, PhD; Cara F. Adamson; Linda Chang, MD; Barry H. Guze, MD; Elizabeth H. Corder, PhD; Ann M. Saunders, PhD; Jonathan L. Haines, PhD; Margaret A. Pericak-Vance, PhD; Allen D. Roses, MD
JAMA. 1995;273(12):942-947. doi:10.1001/jama.1995.03520360056039.
Text Size: A A A
Published online


Objective.  —Cerebral parietal hypometabolism and left-right asymmetry occur early in the course of Alzheimer disease (AD), and the apolipoprotein E type 4 alal- (APOE ε4) is a risk factor for familial AD. To determine if APOE ε4 is associated with lowered brain function in nondemented relatives at risk for familial AD, we studied 12 relatives with APOE ε4 and 19 relatives without APOE ε4. We also compared them with seven patients with probable AD.

Design.  —After grouping subjects according to diagnosis and genotype, brain function measures were compared among groups.

Setting.  —University medical center.

Patients.  —At-risk subjects had mild memory complaints, normal cognitive performance, and at least two relatives with AD. Subjects with APOE ε4 did not differ from those without APOE ε4 in mean age at examination (56.4 vs 55.5 years) or in neuropsychological performance (mean Mini-Mental State Examination score, 28.8 vs 29.3).

Main Outcome Measures.  —Cerebral glucose metabolism was measured using positron emission tomography and fludeoxyglucose F 18.

Results.  —Parietal metabolism was significantly lower and left-right parietal asymmetry was significantly higher in at-risk subjects with APOE ε4 compared with those without APOE ε4. Patients with dementia had significantly lower parietal metabolism than did at-risk subjects with APOE ε4.

Conclusions.  —These results suggest that the inheritance of APOE ε4 is associated with reduced cerebral parietal metabolism and increased asymmetry in nondemented relatives at risk for probable AD. Longitudinal study will determine if glucose metabolic measures provide a means to monitor experimental treatment responses during the early phases of the disorder.(JAMA. 1995;273:942-947)


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

0 Citations

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal
• Rent this article ?

Related Content

Customize your page view by dragging & repositioning the boxes below.