Estrogen Replacement Therapy in Breast Cancer Survivors

Leonard R. Prosnitz, MD
JAMA. 1995;273(8):620. doi:10.1001/jama.1995.03520320027031.
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To the Editor.  —Dr Cobleigh and colleagues1 have done a fine job in reviewing the issues associated with the use of ERT in breast cancer survivors. Although the article is subtitled "A Time for Change," I looked in vain for a specific statement that the prescription of estrogens for women with a history of breast cancer and severe postmenopausal symptoms is justified. They clearly state that clinical trials are justified, but equally clearly the answers from such trials are at least 10 years away. Since one of the issues is medical-legal and since JAMA is an authoritative publication, I would ask Cobleigh and colleagues to indicate what they think is a reasonable position for clinicians to take until the definitive trials are available.


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