We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......

Estrogen Replacement Therapy in Breast Cancer Survivors

Carl D. Atkins, MD
JAMA. 1995;273(8):619. doi:10.1001/jama.1995.03520320027028.
Text Size: A A A
Published online

To the Editor.  —Dr Cobleigh and colleagues1 state that the 27 studies they analyzed "do not consistently demonstrate an increased risk of breast cancer among women who have ever used ERT [estrogen replacement therapy]." However, they fail to recognize that most "negative" studies do not have sufficient power to rule out clinically significant differences (see confidence intervals in Table 1 of Cobleigh et al). Since the most reliable estimates of association of any factor with a disease are obtained from prospective cohort studies rather than retrospective case-control studies, it is important that a prospective analysis based on the Nurses' Health Study2 showed a moderate increase in the risk of breast cancer associated with current use of ERT. Bergkvist et al3 also found an increased risk of breast cancer in their prospective study from Sweden, which, in addition, showed no protection from the addition of progestins.Cobleigh et


Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview




Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Please click the checkbox indicating that you have read the full article in order to submit your answers.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.


Some tools below are only available to our subscribers or users with an online account.

Sign in

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.