0
ARTICLE |

Renal Failure, Rhabdomyolysis, and Phenylpropanolamine

George A. Blewitt, MD; Evan B. Siegel, PhD
JAMA. 1983;249(22):3017. doi:10.1001/jama.1983.03330460017015.
Text Size: A A A
Published online

To the Editor.—  We have reviewed the article by Swenson and colleagues entitled "Acute Renal Failure and Rhabdomyolysis After Ingestion of Phenylpropanolamine-Containing Diet Pills" (1982;248:1216) and offer the following comments.The authors cite reports of "amphetaminelike" CNS stimulation and hypertension as being associated with ingestion of phenylpropanolamine hydrochloride. Several controlled clinical studies, however, have not shown these effects in a cross section of human volunteers at allowed therapeutic doses. Previous publications referred to in this article do not support such adverse affects associated with responsible use of phenylpropanolamine-containing drug products.1,2 Indeed, another reference is a case report of an attempted suicide with a phenylpropanolamine-containing diet aid at 34 times the normal dose.3 Reference 6 referred to five patients who had injected by the intravenous route a "homemade" dosage form of amphetamine.4 Clearly, there is nothing in the article in common with these reports and the purported side

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

Figures

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();