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Apolipoprotein E E4 Allele and Risk of Dementia

Tuula Pirttila, MD; Terho Lehtimaki, MD; Tapio Nikkari, MD; Harry Frey, MD; Kari Mattila, PhD
JAMA. 1995;273(5):375. doi:10.1001/jama.1995.03520290026016.
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To the Editor.  —The association between apo E E4 and AD has been shown in patients with probable AD and in autopsyconfirmed AD cases. However, the specificity of apo E E4 as a risk factor for AD is not known. In a recent letter, Dr Frisoni and colleagues1 proposed that the frequency of apo E E4 is increased also in vascular dementia compared with that in controls.We analyzed apo E phenotypes in 30 patients with vascular dementia and 115 age-matched controls using isoelectric focusing and Western blotting as previously described.2 Vascular dementia was diagnosed according to the guidelines established by the NINDS-AIREN International Workshop.3 Seventeen patients with probable vascular dementia had a typical multi-infarct dementia. Possible vascular dementia was diagnosed in 13 patients, eight of whom were considered to have mixed dementia (ie, possible AD and concomitant significant cerebrovascular disease).No difference in apo E E4

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